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KMID : 1123920060200061629
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 6 p.1629 ~ p.1635
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Inhibitory Effect of Uncaria Sinensis on Matrix Metalloproteinase-9 Activity and Human Aortic smooth Muscle Cell migration
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Kwak Chang-Geun
Choi Dall-Yeong
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Abstract
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The migration of vascular smooth muscle cells (VSMC) and the production of matrix metallopreteinases-9 (MMP-9) may play a key role in the development of atherosclerosis. In this study, we have more extensively investigated the inhibitory effect of UR on MMP-9 activity and TNF- induced human aortic smooth muscle cells (HASMC) migration. The result from gelatin zymography showed that UR inhibited MMP-9 activity in a dose-dependent manner (IC50 = 55 g/ml). In addition, UR strongly inhibited the migration of HASMC induced by TNF-treatment (IC50 = 125 g/ml), although it has very low cytotoxic effect on HASMC (IC50 > 500 g/ml). These results suggest that UR is a potential anti-atherosclerotic agent through inhibition of MMP-9 activity and VSMC migration.
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KEYWORD
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Cho-Deung-San, atherosclerosis, Uncaria sinensis (Oliv.) Havil
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